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Interaksi Obat Receptor Pdf Download

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MessagePosté le: Ven 2 Sep - 01:48 (2016)    Sujet du message: Interaksi Obat Receptor Pdf Download Répondre en citant

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Interaksi Obat Receptor Pdf Download

Some suggestions: Go back to the last page Go to the home page .. hypno-cs or analgesics), where a rapidly achieved high concentra-on is needed, a reduc-on in the rate of absorp-on may result in failure to achieve an adequate eect. Leadership Technology Education Marketing Design More Topics Search . Changes in Urinary pH Only the non-ionised form is lipid-soluble and able to diuse back through the lipid membranes of the tubule cells. Larger molecules, such as plasma proteins, and blood cells are retained within the blood. Changes in Renal Blood Flow Pharmacodynamics Interactions Addi6ve/synergis6c Interac6ons. Effects of changes in GI pH The passage of drugs through mucous membranes by simple passive diusion depends upon the extent to which they exist in the non-ionised lipid-soluble form. Pharmacy-based computer system for monitoring and repor-ng drug interac-ons. .. Some suggestions: Go back to the last page Go to the home page ..

If the serum levels remain within the therapeu-c range the interac-on may not be clinically important Drug Excretion Interactions Most drugs are excreted either in the bile or in the urine. 4. Management of Drug Interactions Obat-obat yang berinteraksi seringkali tetap bisa digunakan bersamaan Ada interaksi obat yang menguntungkan Contoh : probenecid VS penisillin Sifat laporan / informasi IO Kedalaman informasi Waktu penerbitan literature / current literature Clinical VS statistical significance 23/02/15 3 Management of Drug Interactions terdapat 3 derajat keparahan IO yait: : Keparahahan MINOR Bisa terjadi tetapi tidak sigAikan Keparahan MODERATE Pasien mungkin mengalami sesuat: yang dapat membuat kondisinya membur:k karena IO Jika kedua obat memang har:s dig:nakan bersamaan ? Keparahan MAYOR Bila obat dig:nakan bersamaan, maka kemungkinan dapat mengancam jiwa (life threatening) Clinical Signi7icance Grading (Tatro) Tingkat Signifikasi Keamanan Dokumentasi 1 Major Established, Probable or Suspected 2 Moderate Established, Probable or Suspected 3 Minor Established, Probable or Suspected 4 Major / Moderate Possible 5 Minor / Any Possible/ unlikely ! Clinical Signi7icance Grading (Tatro) Established adalah interaksi obat yang memiliki hasil data klinik yang memadai dan telah terbuk- terjadi dalam beberapa peneli-an yang telah dilakukan, baik dari segi efek farmakologis dan interaksi farmakokine-ka. Med Care (1992) 30, 64658. J Clin Pharm Ther (1994) 19, 3417. If two drugs that have the same pharmacological eect are given together the eects can be addi-ve Addi-ve eects can occur with both the main eects of the drugs as well as their adverse eects Example: Methotrexate VS Co-trimoxazole (Bone marrow megaloblastosis due to folic acid antagonism) Antagonis6c/opposing Interac6ons. Dokumen.tips Upload Login / Signup . Changes in Active Renal Tubular Exretion 3. Suspected adalah interaksi yang kemungkinan teradi, beberapa interaksi obat telah memiliki data klinik yang baik dan sebagian interaksi obat membutuhkan peneli-an lebih lanjut.

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